Centrally located between: South Boston, VA Clarksville, VA Buggs Island Lake Oxford, NC and Roxboro, NC
64 miles north of Raleigh-Durham Airport, NC (RDU)
77 miles south of Lynchburg, VA
47 miles east of Danville, VA
Virgilina is on two major highways, US 49 and US 96 and is the nearest place in the county to an interstate, I-85 at Oxford NC. It is also on a direct route to Eastern NC (Hwy 96) and in close proximity to Hyco and Mayo Lakes.